A preliminary study to evaluate the effect of thyroid function on the bone mineral density(BMD)was done. BMD was measured at lumbar spine 2, 3, 4 (A-P view) in 10 euthyroid nodular goiter, 8 primary hypothyroidism and 20 hyperthyroidism patients, perimenopausal or postmenopausal periods. Serum calcium, phosphorus, thyroid hormone concentrations and other parameters were measured to analysis.
The results were as follows.
1. The BMDs of euthyroidism, hypothyroidism, and hyperthyroidism tvere 0.85±0.16gm/㎠ (M±SD), 0.83±0.29 and 0.79±0.16 respectively, without any significant difference, but the BMD of hyperthyroidism was lowest.
2. The BMD of postmenopause of all thyroid disease patients u·as significantly lower than that of perimenopause patients.
3. There was no significant relationship between BMD and serum calcium, phosphorus, T₃, T₄ or duration of treatment for thyroid disease.
In conclusion, the BMD is affected mainly by the age and thyroid function, so attention to osteoporosis must be considered for the patients of thyroid disease in menopause.
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